O Estudo da vasculatura dos astrocitomas do ponto de vista histoquímico auxiliando na escolha terapêutica: uma revisão sistemática

Study of astrocytomas vasculature in the histochemical view: a systematic review

Ana Paula  de  Souza  e  Pinto1, Anacássia  Fonseca  de  Lima1, Juliana  Pedrosa  de  Holanda Marques1, Livia Bandeira Costa1, Roberto José Vieira de Mello1, Luciano Tavares Montenegro1, Nicodemos Teles de Pontes Filho1

ABSTRACT

CONTEXT: Angiogenesis is a prerequisite for tumor growth and  expansion. Astrocytoma constitutes the main histological type among  primary tumors of the central nervous system. Therefore, the study of angiogenesis  in astrocytomas account for the vascular supply of this type of tumor. OBJECTIVE: Undertake a systematic review of articles demonstrating if angiogenesis  in astrocytomas using immunohistochemistry can help in determining therapy. METHODS: We  conducted  a  systematic review with a  search  in the  databases LILACS,  SciELO, PubMed / Medline and  Old Medline and  published between 1966  and  2009. For selection of the study the following criteria  were  considered: