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Role of ghrelin on depressive rand

the effects of treatment: brief Review

Simone Carneiro Nascimento1, Marcelo Moraes Valença2                                                                                                                                                                     

AbstrAct

Mental disorders are among the major diseases of era, and depression has shown to be the most prevalent and disabling ones. Ghrelin is an important appetite-regulating hormone that is involved on mood regulation and seems to play an important role in the pathogenesis of depression.  It  was demonstrated that the acute administration of this hormone reverse depressive symptoms, however it also was demonstrated that it chronic central ghrelin administration increases  both  anxiety and  depression-like behaviour. The findings are  still controversial and despite the benefits promoted by some medications, they still have the change  on weight as a side effect. There are much more to be enlightened about this mind-body connection.

Key words: Ghrelin, Depressive disorders, Depression. Anxiety, Treatments.

Papel da grelina nos transtornos depressivos e os efeitos do tratamento: breve revisão